General Information

  • ID:  hor000478
  • Uniprot ID:  Q5QRY7
  • Protein name:  Grb-AST-B1
  • Gene name:  astB
  • Organism:  Gryllus bimaculatus (Two-spotted cricket)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gryllus (genus), Gryllinae (subfamily), Gryllidae (family), Grylloidea (superfamily), Gryllidea (infraorder), Ensifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GWQDLNGGW
  • Length:  9(37-45)
  • Propeptide:  AWRDLSGGWGKRAWNNLGSAWGKRGWRDLNGGWGKRGWQDLNGGWGKRGWQDLNGGWGKRGWQDLNGGWGKRGRQSPLCSVRSCC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Metamorphosis and muscle contractions
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5QRY7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000478_AF2.pdbhor000478_ESM.pdb

Physical Information

Mass: 117497 Formula: C47H61N13O14
Absent amino acids: ACEFHIKMPRSTVY Common amino acids: G
pI: 3.75 Basic residues: 0
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -107.78 Boman Index: -850
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 43.33
Instability Index: 5472.22 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1375

Literature

  • PubMed ID:  16061202
  • Title:  Discovering Neuropeptides in Caenorhabditis Elegans by Two Dimensional Liquid Chromatography and Mass Spectrometry